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Keap1-Nrf2-IN-25

CAT: 0804-HY-168922Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168922Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Keap1-Nrf2-IN-25 (Compound 19) is a potent Keap1-Nrf2 inhibitor (IC50 of 0.55 μM) with Keap1 binding affinity (Kd of 0.50 μM). Keap1-Nrf2-IN-25 activates Nrf2, reduces ROS and pro-inflammatory cytokines (IL-1β, IL-6). Keap1-Nrf2-IN-25 exerts protective effects against DSS -induced colitis[1].
CAS Number
3100306-80-4
UNSPSC
12352005
Target
Interleukin Related; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
OC(CN(S(=O)(C1=C(C)C=C(C)C=C1C)=O)C2=CC=C(N[C@H](CC(O)=O)C)C3=CC=CC=C32)=O
Molecular Formula
C25H28N2O6S
Molecular Weight
484.56
References & Citations
[1]Zhao Z, et al. Discovery of β-amino acid substituted naphthalene sulfonamide derivatives as potent Kelch-like ECH-associated protein 1-nuclear factor erythroid 2-related factor 2 (Keap1-Nrf2) protein-protein interaction inhibitors for ulcerative colitis management. Eur J Med Chem. 2025 Feb 13;288:117384.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1; IL-6

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