Keap1-Nrf2-IN-11

Keap1-Nrf2-IN-11

• CAS Number: 2796292-75-4
• UNSPSC Description: Keap1-Nrf2-IN-11 (compound 6k) is a Keap1-Nrf2 inhibitor with KD2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research[1].
• Target Antigen: Keap1-Nrf2; NO Synthase; ROS Kinase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;NF-κB;Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-11.html
• Solubility: 10 mM in DMSO
• Smiles: O=S(N(C1=C2C(C=CC=C2)=C(C=C1)N(S(=O)(C3=CC=C(C=C3)NC(CCN4CCN(CC4)CC)=O)=O)CC(N)=O)CC(N)=O)(C5=CC=C(C=C5)OC)=O
• Molecular Weight: 765.90
• References & Citations: [1]Liu G, et al. Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides. J Med Chem. 2022 Jun 23;65(12):8289-8302.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported