Keap1-Nrf2-IN-11

• UNSPSC Description:

  Keap1-Nrf2-IN-11 (compound 6k) is a Keap1-Nrf2 inhibitor with KD2 value of 0.21 nM. Keap1-Nrf2-IN-11 inhibits the productions of ROS and NO and the expression of TNF-α. Keap1-Nrf2-IN-11 relieves inflammations by increasing the Nrf2 nuclear translocation. Keap1-Nrf2-IN-11 can be used for anti-inflammatory research[1].

• Target Antigen:

  Keap1-Nrf2; NO Synthase; ROS Kinase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;NF-κB;Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/keap1-nrf2-in-11.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=S(N(C1=C2C(C=CC=C2)=C(C=C1)N(S(=O)(C3=CC=C(C=C3)NC(CCN4CCN(CC4)CC)=O)=O)CC(N)=O)CC(N)=O)(C5=CC=C(C=C5)OC)=O

• Molecular Weight:

  765.90

• References & Citations:

  [1]Liu G, et al. Crystallography-Guided Optimizations of the Keap1-Nrf2 Inhibitors on the Solvent Exposed Region: From Symmetric to Asymmetric Naphthalenesulfonamides. J Med Chem. 2022 Jun 23;65(12):8289-8302.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2796292-75-4