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Keap1-Nrf2-IN-13

CAT: 0804-HY-150579-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-150579-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Keap1-Nrf2-IN-13 is a Keap1-Nrf2 protein–protein interaction (PPI) inhibitor with an IC50 value of 0.15 μM. Keap1-Nrf2-IN-13 has strong binding affinities to the Keap1 protein by forming hydrogen bond with the key polar residues (Asn414, Arg415, Arg483, Gln530) . Keap1-Nrf2-IN-13 can be used in the research of oxidative stress-related and inflammatory diseases, including pulmonary fibrosis, chronic obstructive pulmonary disorder (COPD) and cancers[1].
CAS Number
2456294-92-9
UNSPSC
12352005
Target
Keap1-Nrf2
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/keap1-nrf2-in-13.html
Purity
96.77
Solubility
DMSO : 300 mg/mL (ultrasonic)
Smiles
O=S(N([C@@H](C)C(O)=O)CC1=CC=CC=C1CN([C@@H](C)C(O)=O)S(=O)(C2=CC=C(OC)C=C2)=O)(C3=CC=C(OC)C=C3)=O
Molecular Formula
C28H32N2O10S2
Molecular Weight
620.69
References & Citations
[1][1] Dhulfiqar Ali Abed, et al. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. Bioorg Med Chem. 2020 Mar 15;28 (6) :115343.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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