Keap1-Nrf2-IN-5

Keap1-Nrf2-IN-5

• CAS Number: 2696272-70-3
• UNSPSC Description: Keap1-Nrf2-IN-5 (compound 1) is a potent Keap1-Nrf2 PPI (Keap1-Nrf2 protein−protein interaction) inhibitor with an IC50 of 4.1 µM, Kd of 3.7 µM[1].
• Target Antigen: Keap1-Nrf2
• Type: Reference compound
• Related Pathways: NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H](NC([C@H](NC([C@H]1N(C(C)=O)CCC1)=O)CO2)=O)CSCC3=CC=CC=C3C2=O)N(C)C
• Molecular Weight: 490.57
• References & Citations: [1]Begnini F, et al. Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction. J Med Chem. 2022 Feb 24;65(4):3473-3517.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported