Poneratoxin

CAT: 0804-HY-P10234Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-P10234Size:1 Each
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Description
Poneratoxin is the modulator for voltage-gated sodium channel (NaV, EC50 for NaV1.6 and NaV1.7 is 97 nM and 2.3 µM), that lowers the voltage threshold for activation and inhibits the inactivation of channels, enhances the excitability of neurons, and leads to the transmission of pain signals[1].
CAS Number
[137084-94-7]
UNSPSC
12352209
Target
Sodium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/poneratoxin.html
Solubility
10 mM in DMSO
Smiles
C(=O)([C@H]1N(C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@@H](NC([C@H](CC3=CC=CC=C3)N)=O)CC(C)C)=O)CCC2)CC(C)C)=O)CC(C)C)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)CO)=O)CC(C)C)=O)CC(C)C)=O)CCSC)=O)[C@@H](C)O)=O)CCC1)N4[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC5=CN=CN5)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCC(N)=O)=O)C)=O)CC(O)=O)=O)=O)[C@H](CC)C)=O)C)=O)CCC(N)=O)=O)[C@H](CC)C)=O)[C@H](C)C)=O)CCC4
Molecular Formula
C129H215N33O31S
Molecular Weight
2756.35
References & Citations
[1]Robinson SD, et al., Ant venoms contain vertebrate-selective pain-causing sodium channel toxins. Nat Commun. 2023 May 23;14 (1) :2977.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Citation 01
Bioorg Med Chem. 2025 Oct 9:132:118436.|Sci Rep. 2025 Jul 16;15 (1) :25854.|PLoS Biol. 2025 Nov 24;23 (11) :e3003513.

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