Cholera toxin

• UNSPSC Description:

  Cholera toxin (Choleragen), an AB(5)-subunit toxin, enters host cells by binding the ganglioside GM1 at the plasma membrane (PM) and travels retrograde through the trans-Golgi Network into the endoplasmic reticulum (ER)[1]. Choleragen activates adenylate cyclase by catalyzing ADP-ribosylation of Gs alpha, the stimulatory guanine nucleotide-binding protein[2].

• Target Antigen:

  Adenylate Cyclase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Purity:

  96.0

• Solubility:

  H2O : 10 mg/mL

• Smiles:

  [Cholera toxin]

• References & Citations:

  [1]Kellner A, et al. A binding motif for Hsp90 in the A chains of ADP-ribosylating toxins that move from the endoplasmic reticulum to the cytosol. Cell Microbiol. 2019;21(10):e13074.|[2]Tsai SC, et al. Stimulation of choleragen enzymatic activities by GTP and two soluble proteins purified from bovine brain. J Biol Chem. 1988;263(4):1768-1772.|[3]Wernick NL, et al. Cholera toxin: an intracellular journey into the cytosol by way of the endoplasmic reticulum. Toxins (Basel). 2010;2(3):310-325.

• Shipping Conditions:

  Isolate blue ice and the product with bubble pack to avoid direct contact

• Storage Conditions:

  Store at 4°C, do not freeze

• Clinical Information:

  Launched

• CAS Number:

  9012-63-9