Keap1-Nrf2-IN-4

Keap1-Nrf2-IN-4

• CAS Number: 2851480-01-6
• UNSPSC Description: Keap1-Nrf2-IN-4 is a potent neddylation inhibitor. Keap1-Nrf2-IN-4 exhibits potent anti-proliferation activity against MGC-803 cells (IC50=2.55 μM). Keap1-Nrf2-IN-4 blocks the migration ability and induces apoptosis of gastric cancer cells. Keap1-Nrf2-IN-4 inhibits tumor growth without obvious toxicity[1].
• Target Antigen: Apoptosis; E1/E2/E3 Enzyme
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/keap1-nrf2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: CCCCCC1=CC=C(C=C1)NC(C2CCN(CC2)C/C=C/C3=CC=CC=C3)=O
• Molecular Weight: 390.56
• References & Citations: [1]Wang B, et al. Discovery of a cinnamyl piperidine derivative as new neddylation inhibitor for gastric cancer treatment. Eur J Med Chem. 2021; 226:113896.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported