ERα degrader 5

ERα degrader 5

• CAS Number: 2941268-96-6
• UNSPSC Description: ERα degrader 5 (Compound 40) is a selective, orally bioavailable estrogen receptor (ER) degrader (SERD) with an EC50 of 1.1 nM against ERα. ERα degrader 5 shows antitumor effect in vivo[1].
• Target Antigen: Estrogen Receptor/ERR
• Type: Reference compound
• Related Pathways: Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/erα-degrader-5.html
• Solubility: 10 mM in DMSO
• Smiles: CC(F)(C1=C(C2=C(C3=CC=C4NN=CC4=C3S2)OC5=CC=C(C=C5)OC6CN(C6)CCCF)C=CC(F)=C1)F
• Molecular Weight: 555.59
• References & Citations: [1]Zhengyu Lu, et al. Discovery of Thieno[2,3-e]indazole Derivatives as Novel Oral Selective Estrogen Receptor Degraders with Highly Improved Antitumor Effect and Favorable Druggability. J Med Chem. 2022 Apr 14;65(7):5724-5750.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported