Taltobulin intermediate-11

CAT: 0804-HY-46005Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-46005Size:1 Each
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Description
Taltobulin intermediate-11 is an intermediate in the synthesis of Taltobulin (HY-15584) . Taltobulin is a common toxin component in ADC preparation (ADC Cytotoxin), and it is also a powerful tubulin (Microtubule/Tubulin) inhibitor. Taltobulin disrupts tubulin polymerization, induces mitotic arrest, and induces apoptosis[1].
CAS Number
[1822561-77-2]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/taltobulin-intermediate-11.html
Solubility
10 mM in DMSO
Smiles
O=C(NC(C(C)(C)C1=CC=CC=C1)C(OC)=O)OC(C)(C)C
Molecular Formula
C17H25NO4
Molecular Weight
307.38
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63 (8) :1838-45.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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