PPARγ modulator-4

• Description :

  PPARγ modulator-4 (Compound (I) ) is a PPARγ inhibitor (KD: 3.75 μM) . PPARγ modulator-4 can inhibit CDK5-mediated phosphorylation of PPARγ at Ser245. PPARγ modulator-4 can be used in insulin resistance research[1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Endocrinology; Metabolic Disease

• Smiles :

  O=C1OC(C(C2=CC=C(C=C2)Br)=C1O)C3=CC=CC(O)=C3

• Molecular Formula :

  C16H11BrO4

• Molecular Weight :

  347.16

• References & Citations :

  [1]Cazzaniga G, et al. Enhancing the activity of γ-hydroxy lactone derivatives as innovative peroxisome proliferator-activated receptor γ non-agonists inhibiting cyclin-dependent kinase 5-mediated phosphorylation. Eur J Med Chem. 2025 Aug 5;292:117657.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ