PPARγ/GR modulator 1

• UNSPSC Description:

  PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1].

• Target Antigen:

  Glucocorticoid Receptor; PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Immunology/Inflammation;Metabolic Enzyme/Protease;Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pparγ-gr-modulator-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(OC1=O)=CC(O)=C1C(/C=C/C2=CC=NC(F)=C2)=O

• Molecular Weight:

  275.23

• References & Citations:

  [1]Ahn S, et, al. Discovery of PPARγ and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114927.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported