PPARγ/GR modulator 1

• Description :

  PPARγ/GR modulator 1 is an orally active dual agonist of PPARγ and glucocorticoid receptor (GR), with Kis of 3.3 and 33.6 μM, respectively. PPARγ/GR modulator 1 can be used for the research of metabolic diseases, such as diabetes[1].

• UNSPSC :

  12352005

• Target :

  Glucocorticoid Receptor; PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pparγ-gr-modulator-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC(OC1=O)=CC(O)=C1C(/C=C/C2=CC=NC(F)=C2)=O

• Molecular Formula :

  C14H10FNO4

• Molecular Weight :

  275.23

• References & Citations :

  [1]Ahn S, et, al. Discovery of PPARγ and glucocorticoid receptor dual agonists to promote the adiponectin and leptin biosynthesis in human bone marrow mesenchymal stem cells. Eur J Med Chem. 2023 Jan 5;245 (Pt 1) :114927.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ