ABP/PPAR modulator 1

• Description :

  ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα, PPARγ and PPARδ) . ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model[1].

• UNSPSC :

  12352211

• Target :

  FABP; PPAR

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease; Inflammation/Immunology

• Smiles :

  COC1=CC=C(/C=C/C2=CC(OCC3=CC=C(OC(C)(C)C(N[C@@H](C(O)=O)CC(C)C)=O)C=C3)=CC(OC)=C2)C=C1

• Molecular Formula :

  C33H39NO7

• Molecular Weight :

  561.67

• References & Citations :

  [1]Chen Y, et al. Discovery of the first-in-class FABP/PPAR multiple modulator for the treatment of metabolic dysfunction-associated steatohepatitis. Eur J Med Chem. 2025 Jul 5; 291:117635.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARα; PPARγ; PPARδ