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ABP/PPAR modulator 1

CAT: 0804-HY-172883Size: 1 EachDry Ice: NoHazardous: No
HY-1728831 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABP/PPAR modulator 1 is an orally active FABP and PPAR multiple modulator (IC50s of 0.65 μM and 1.08 μM for FABP1 and FABP4, EC50 s of 9.19 μM, 2.20 μM and 1.58 μM for PPARα, PPARγ and PPARδ) . ABP/PPAR modulator 1 has potent anti-metabolic dysfunction-associated steatohepatitis (MASH) activity. ABP/PPAR modulator 1 dose-dependently ameliorates multiple pathological characteristics of fatty liver in WD + Carbon tetrachloride-induced MASH mice model[1].
UNSPSC
12352211
Target
FABP; PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
COC1=CC=C(/C=C/C2=CC(OCC3=CC=C(OC(C)(C)C(N[C@@H](C(O)=O)CC(C)C)=O)C=C3)=CC(OC)=C2)C=C1
Molecular Formula
C33H39NO7
Molecular Weight
561.67
References & Citations
[1]Chen Y, et al. Discovery of the first-in-class FABP/PPAR multiple modulator for the treatment of metabolic dysfunction-associated steatohepatitis. Eur J Med Chem. 2025 Jul 5; 291:117635.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ; PPARδ

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