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PPARγ/δ modulator 2

CAT: 0804-HY-170581Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-170581Size:1 Each
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Description
PPARγ/δ modulator 2 (Compound 3h) is a PPARγ agonist and PPARδ antagonist. The Ki values for PPARγ and PPARδ are 2.8 μM and 43 nM, respectively. PPARγ/δ modulator 2 significantly enhances the production of Adiponectin and promotes adipogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) . PPARγ/δ modulator 2 can be used in the study of metabolic disorders associated with hypoadiponectinemia[1].
UNSPSC
12352005
Target
PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease
Smiles
O[C@H](C[Se]1)[C@@H](O)[C@@H]1CN2C(N=C(Cl)N=C3NCC4=CC=CC(I)=C4)=C3N=C2
Molecular Formula
C17H17ClIN5O2Se
Molecular Weight
564.67
References & Citations
[1]Choi H, et al. Design, synthesis and biological evaluation of truncated 1'-homologated 4'-selenonucleosides as PPARγ/δ dual modulators. Bioorg Chem. 2025 Jan;154:108042.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARγ; PPARδ

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