PPARγ/δ modulator 2

• Description :

  PPARγ/δ modulator 2 (Compound 3h) is a PPARγ agonist and PPARδ antagonist. The Ki values for PPARγ and PPARδ are 2.8 μM and 43 nM, respectively. PPARγ/δ modulator 2 significantly enhances the production of Adiponectin and promotes adipogenic differentiation of human bone marrow mesenchymal stem cells (hBM-MSCs) . PPARγ/δ modulator 2 can be used in the study of metabolic disorders associated with hypoadiponectinemia[1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Metabolic Disease

• Smiles :

  O[C@H](C[Se]1)[C@@H](O)[C@@H]1CN2C(N=C(Cl)N=C3NCC4=CC=CC(I)=C4)=C3N=C2

• Molecular Formula :

  C17H17ClIN5O2Se

• Molecular Weight :

  564.67

• References & Citations :

  [1]Choi H, et al. Design, synthesis and biological evaluation of truncated 1'-homologated 4'-selenonucleosides as PPARγ/δ dual modulators. Bioorg Chem. 2025 Jan;154:108042.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ; PPARδ