PPARγ/δ modulator 1

• Description :

  PPARγ/δ modulator 1 (compound 3e) is a potent PPAR modulator. PPARγ/δ modulator 1 is a PPARδ antagonist and a PPARγ partial agonist , with Ki values of 14.4 nM and 5.31 μM, respectively. PPARγ/δ modulator 1 has the EC50 of 7.3 and 12.6 μM for PPARδ corepression and adiponectin production, respectively[1].

• CAS Number :

  [2089159-00-0]

• UNSPSC :

  12352005

• Target :

  PPAR

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pparγ-δ-modulator-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1[C@H]([C@@H]([Se][C@@H]1C(NC)=O)N2C3=C(N=C2)C(NCC4=CC=CC(I)=C4)=NC(Cl)=N3)O

• Molecular Formula :

  C18H18ClIN6O3Se

• Molecular Weight :

  607.69

• References & Citations :

  [1]An S, et al. Selenium bioisosteric replacement of adenosine derivatives promoting adiponectin secretion increases the binding affinity to peroxisome proliferator-activated receptor δ. Bioorg Med Chem. 2020 Jan 1;28 (1) :115226.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ; PPARδ