PPARγ modulator-2

• Description :

  PPARγ modulator-2 (Compound (R) -2n) is the reversible modulator for PPARγ that inhibits PPARγ ligand-binding domain (LBD) with an IC50 of 41 nM. PPARγ modulator-2 reduces blood glucose, improves the glucose tolerance and insulin tolerance, and exhibits anti-diabetic efficacy in db/db mouse models[1].

• UNSPSC :

  12352005

• Target :

  PPAR

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Metabolic Disease

• Smiles :

  O=S1(C2=CC=C(C=C2)OS(C3=CC=C(C=C3)C)(=O)=O)=N[Se]C4=CC(OS(C5=CC=C(C=C5)C)(=O)=O)=CC=C41

• Molecular Formula :

  C26H21NO7S3Se

• Molecular Weight :

  634.60

• References & Citations :

  [1]Chen F, et al., Identification of Novel Organo-Se BTSA-Based Derivatives as Potent, Reversible, and Selective PPARγ Covalent Modulators for Antidiabetic Drug Discovery. J Med Chem. 2025 Jan 9;68 (1) :819-831.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PPARγ

• CAS Number :

  [2897652-01-4]