PPARγ modulator-3

• Description:

  PPARγ modulator-3 (Compound 11) is a peroxisome proliferator-activated receptor γ (PPARγ) modulator with a KD value of 186 nM. PPARγ modulator-3 is promising for research of insulin resistance (IR) -related diseases, such as type 2 diabetes mellitus (T2DM) and metabolic syndrome[1].

• UNSPSC:

  12352005

• Target:

  PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C(O)COC1=CC=CC(C(C(C2=CC=C(Br)C=C2)=C3O)OC3=O)=C1

• Molecular Formula:

  C18H13BrO6

• Molecular Weight:

  405.20

• References & Citations:

  [1]Cazzaniga G, et al. Enhancing the Activity of γ-Hydroxy Lactone Derivatives as Innovative Peroxisome Proliferator-Activated Receptor γ Non-Agonists Inhibiting Cyclin-Dependent Kinase 5-Mediated Phosphorylation[J]. European Journal of Medicinal Chemistry, 2025: 117657.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PPARγ