SEH/PPARδ modulator 1

• Description:

  SEH/PPARδ modulator 1 is a sEH/PPARδ dual modulator. sEH/PPARδ modulator 1 can inhibit sEH with an IC50 of 0.46 μM and activate PPARδ with an EC50 of 0.12 μM. sEH/PPARδ modulator 1 can be used for the researches of inflammation, metabolic and cardiovascular disease[1].

• UNSPSC:

  12352101

• Target:

  Epoxide Hydrolase; PPAR

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Field of Research:

  Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

• Smiles:

  CC1=CC(C(F)(F)F)=CC=C1NC(NCCOC2=CC=C(C=C2)CCC(O)=O)=O

• Molecular Formula:

  C20H21F3N2O4

• Molecular Weight:

  410.39

• References & Citations:

  [1]Ge X, et al. Development of Potent and Selective Dual PPARδ/sEH Modulators from an AI-Designed Scaffold. J Med Chem. 2025 Oct 9;68 (19) :20636-20656.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PPARδ