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HSD17B13/PPAR modulator-1

CAT: 0804-HY-179015Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179015Size:1 Each
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Description
HSD17B13/PPAR modulator-1 (Compound 17) is a HSD17B13/PPAR multitarget modulator. HSD17B13/PPAR modulator-1 is an inhibitor of HSD17B13, with its IC50 value being 0.91 μM. HSD17B13/PPAR modulator-1 is a PPAR agonist, with the EC50 values for PPARα, PPARδ, and PPARγ being 1.55, 0.12, and 0.01 μM respectively. HSD17B13/PPAR modulator-1 can significantly improve liver function, regulate lipid metabolism, alleviate fibrosis, and exert antioxidant and anti-inflammatory effects in the model of metabolic dysfunction-related steatohepatitis (MASH) . HSD17B13/PPAR modulator-1 can be used for the study of MASH[1].
UNSPSC
12352005
Target
17β-HSD; PPAR
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(C1=C(C)N=C(S1)C2=CC(F)=C(F)C(O)=C2F)N(CC3=CC(C)=C(C(C)=C3)OC(C)(C(O)=O)C)CC4=CC=CC=C4
Molecular Formula
C31H29F3N2O5S
Molecular Weight
598.63
References & Citations
[1]Liang Z, et al. Discovery of the First-In-Class HSD17B13/PPAR Multitarget Modulators for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis. J Med Chem. 2025 Nov 13;68 (21) :22938-22958.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PPARα; PPARγ; PPARδ

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