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PDE4-IN-26

CAT: 0804-HY-172135Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172135Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4-IN-26 (Compound A5) is an orally active and highly selective PDE4 inhibitor. PDE4-IN-26 has anti-inflammatory activity and can inhibit the phosphorylation of p38 MAPK. In mouse models of acute lung injury and chronic obstructive pulmonary disease, PDE4-IN-26 can improve pulmonary inflammation, injury and fibrosis, promote sputum secretion and relieve cough in mice. PDE4-IN-26 can be used for the research of lung injury-related diseases[1].
UNSPSC
12352005
Target
P38 MAPK; Phosphodiesterase (PDE)
Related Pathways
MAPK/ERK Pathway; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
FC(OC1=C(OCC2CC2)C=C(C3=NC4=C(N3)C=CC=C4C(NC5=NC=CS5)=O)C=C1)F
Molecular Formula
C22H18F2N4O3S
Molecular Weight
456.47
References & Citations
[1]Li M, et al. Design, Synthesis, and Evaluation of Selective PDE4 Inhibitors for the Therapy of Pulmonary Injury. J Med Chem. 2025 Feb 13;68 (3) :3837-3857.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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