PDE4-IN-8

PDE4-IN-8

• CAS Number: 2415085-45-7
• UNSPSC Description: PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM)[1].
• Target Antigen: Interleukin Related; Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pde4-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: CCCOC1=C(OC)C=CC(C2=CN=CC([C@]3([H])CB(OC3)O)=C2)=C1
• Molecular Weight: 327.18
• References & Citations: [1]Joseph Walter Strohbach, et al. Inhibiteurs de pde4 contenant du bore. WO2020070651A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported