PDE4-IN-8

• UNSPSC Description:

  PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM)[1].

• Target Antigen:

  Interleukin Related; Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/pde4-in-8.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCCOC1=C(OC)C=CC(C2=CN=CC([C@]3([H])CB(OC3)O)=C2)=C1

• Molecular Weight:

  327.18

• References & Citations:

  [1]Joseph Walter Strohbach, et al. Inhibiteurs de pde4 contenant du bore. WO2020070651A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2415085-45-7