PDE4-IN-8

CAT: 0804-HY-144684Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-144684Size:1 Each
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Description
PDE4-IN-8 (Example 5) is a potent PDE4 inhibitor with an IC50 of 0.93 nM for PDE4B2.PDE4-IN-8 has little effect on IL13 (IC50=4.04 nM), IL4 (IC50=36.33 nM), IFNy (IC50=2394 nM) [1].
CAS Number
[2415085-45-7]
UNSPSC
12352005
Target
Interleukin Related; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pde4-in-8.html
Solubility
10 mM in DMSO
Smiles
CCCOC1=C(OC)C=CC(C2=CN=CC([C@]3([H])CB(OC3)O)=C2)=C1
Molecular Formula
C18H22BNO4
Molecular Weight
327.18
References & Citations
[1]Joseph Walter Strohbach, et al. Inhibiteurs de pde4 contenant du bore. WO2020070651A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-13; IL-4; PDE4

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