PDE4-IN-17
CAT:
804-HY-162583
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PDE4-IN-17
- UNSPSC Description: PDE4-IN-17 (compound 4e) is a potent PDE4 inhibitor. PDE4-IN-17 inhibits PDE4B and PDE4D with IC50s of 10.0 and 15.2 nM, respectively. PDE4-IN-17 has good oral bioavailability (F=66%) and longer half-life (t1/2=2.0 h) in SD rats[1].
- Target Antigen: Phosphodiesterase (PDE)
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/pde4-in-17.html
- Smiles: O=C(CN1C=CN=C1)C2=CC=C(OC)C3=C2C=C(C4CC4)O3
- Molecular Weight: 296.32
- References & Citations: [1]Xia C, et al. Discovery of 7-alkoxybenzofurans as PDE4 inhibitors with hepatoprotective activity in D-GalN/LPS-induced hepatic sepsis. Eur J Med Chem. 2024 Jun 7;275:116576.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported