Products for Research Use Only
RegisterLogin

PDE4-IN-12

CAT: 0804-HY-151174Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-151174Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively) . PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs) [1].
CAS Number
2901084-32-8
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde4-in-12.html
Solubility
10 mM in DMSO
Smiles
COC1=C(C=C2OC3=C(C(OCC4=CC=NC=C4)=C5C=CC(C)(OC5=C3)C)C(C2=C1C/C=C(C)\C)=O)OCC6CC6
Molecular Formula
C34H35NO6
Molecular Weight
553.64
References & Citations
[1]Liu H, et al. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur J Med Chem. 2022 Aug 9;242:114631.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10; PDE4; PDE5; PDE7; PDE8

Related Products

CatalogName
HY-155692PDE4-IN-13
HY-144684PDE4-IN-8
HY-159654PDE4-IN-19
HY-W787896-01PDE4-IN-25
HY-162583PDE4-IN-17
HY-115871PDE4-IN-4
HY-179639PDE4-IN-30
HY-169981PDE4-IN-24
HY-161381PDE4-IN-15
HY-W186242-01PDE4-IN-16

Alternative Products

CatalogName
T63912-01PDE4-IN-12
BA8215-10PDE4-IN-14
T211159-01PDE4-IN-29
T210960-01PDE4-IN-28
T210238-01PDE4-IN-17
T200132-01PDE4-IN-19
T62969-01PDE4-IN-6
T60934-01PDE4-IN-9
T50023-01PDE4-IN-20
T61295-01PDE4-IN-5

Popular Products