PDE4-IN-12

• Description:

  PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively) . PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs) [1].

• UNSPSC:

  12352005

• Target:

  Phosphodiesterase (PDE)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pde4-in-12.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C=C2OC3=C(C(OCC4=CC=NC=C4)=C5C=CC(C)(OC5=C3)C)C(C2=C1C/C=C(C)\C)=O)OCC6CC6

• Molecular Formula:

  C34H35NO6

• Molecular Weight:

  553.64

• References & Citations:

  [1]Liu H, et al. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur J Med Chem. 2022 Aug 9;242:114631.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  PDE10; PDE4; PDE5; PDE7; PDE8

• CAS Number:

  [2901084-32-8]