PDE4-IN-12

PDE4-IN-12

• CAS Number: 2901084-32-8
• UNSPSC Description: PDE4-IN-12 is a potent pan-PDE4 inhibitor, with IC50s of 3.5 and 15 nM for PDE4 and PDE7, respectively (SI=2.71 and 4.27, respectively). PDE4-IN-12 shows well tolerated, can be used in study of inflammatory bowel diseases (IBDs)[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde4-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: COC1=C(C=C2OC3=C(C(OCC4=CC=NC=C4)=C5C=CC(C)(OC5=C3)C)C(C2=C1C/C=C(C)\C)=O)OCC6CC6
• Molecular Weight: 553.64
• References & Citations: [1]Liu H, et al. Discovery of novel PDE4 inhibitors targeting the M-pocket from natural mangostanin with improved safety for the treatment of Inflammatory Bowel Diseases. Eur J Med Chem. 2022 Aug 9;242:114631.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported