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PDE4-IN-4

CAT: 0804-HY-115871Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115871Size:1 Each
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Description
PDE4-IN-4 is a dual M3 (pIC50 = 10.2) antagonist-PDE4 (pIC50 = 8.8) inhibitor for the inhaled research of pulmonary diseases.
CAS Number
1793069-00-7
UNSPSC
12352005
Target
MAChR; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/pde4-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(CN[C@H](C2=CC=CC=C2)C(O[C@H]3CN4CCC3CC4)=O)S1)O[C@H](C5=CC=C(OC)C(OC)=C5)CC6=C(Cl)C=[N+]([O-])C=C6Cl
Molecular Formula
C36H37Cl2N3O7S
Molecular Weight
726.67
References & Citations
[1]Armani E, et al. Discovery of M3 Antagonist-PDE4 Inhibitor Dual Pharmacology Molecules for the Treatment of Chronic Obstructive Pulmonary Disease. J Med Chem. 2021 Jul 8;64 (13) :9100-9119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3; PDE4

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