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PDE4-IN-29

CAT: 0931-T211159-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211159-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2815361-45-4
Target
PDE
Related Pathways
Metabolism
Bioactivity
PDE4-IN-29 (Compound 55) is an orally active and selective inhibitor of PDE4, targeting subtypes such as PDE4A1, PDE4B2, and PDE4D3, with an IC50 value for PDE4D3 of less than 5 nM. It inhibits the degradation of cyclic adenosine monophosphate (cAMP), elevating intracellular cAMP levels and suppressing the release of inflammatory mediators like TNF-α. PDE4-IN-29 holds potential for research in inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.
Smiles
O=C1C=2C(C(=O)N1[C@H](CS(C)(=O)=O)C3=CC(OCC)=C(OC)C=C3)=C(NC(C)=O)C=CC2C(CCCC)O
Molecular Formula
C27H34N2O8S
Molecular Weight
546.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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