PDE4-IN-29

• Target:

  PDE

• Related Pathways:

  Metabolism

• Bioactivity:

  PDE4-IN-29 (Compound 55) is an orally active and selective inhibitor of PDE4, targeting subtypes such as PDE4A1, PDE4B2, and PDE4D3, with an IC50 value for PDE4D3 of less than 5 nM. It inhibits the degradation of cyclic adenosine monophosphate (cAMP), elevating intracellular cAMP levels and suppressing the release of inflammatory mediators like TNF-?. PDE4-IN-29 holds potential for research in inflammatory diseases such as psoriasis, atopic dermatitis, and chronic obstructive pulmonary disease.

• Smiles:

  O=C1C=2C(C(=O)N1[C@H](CS(C)(=O)=O)C3=CC(OCC)=C(OC)C=C3)=C(NC(C)=O)C=CC2C(CCCC)O

• Molecular Formula:

  C27H34N2O8S

• Molecular Weight:

  546.63

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2815361-45-4