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PDE4-IN-24

CAT: 0804-HY-169981Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169981Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE4-IN-24 (compoud 14h) is a potent inhibitor of PDE4D with the IC50 of 0.57 nM and >4100-fold selectivity over other PDE families. PDE4-IN-24 plays an important role in inflammatory disease[1].
CAS Number
3087059-29-5
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
O=C(NCC1=NC=CC=N1)C2=CSC(C3=CC=C(C(OCC4CC4)=C3)OC(F)F)=N2
Molecular Formula
C20H18F2N4O3S
Molecular Weight
432.44
References & Citations
[1]Dengqin He, et al. Design, Synthesis, and Biological Evaluation of New Selective PDE4 Inhibitors for Topical Treatment of Psoriasis. J Med Chem. 2024 Nov 28;67 (22) :20353-20371.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4

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