MTX-216

• Description:

  MTX-216 is a dual ATP-competitive inhibitor of PI3K and EGFR. MTX-216 cosuppresses Ki-67 and ribosomal S6 phosphorylation and induces apoptosis in NF1LOF cells. MTX-216 suppresses the activity of SYK kinase, with an IC50 of 281 nM. MTX-216 is used in the research of Melanoma[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; EGFR; PI3K; Syk

• Related Pathways:

  Apoptosis; JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  N#CC1=C(NC2=CC=C(C(Cl)=C2)F)C3=CC(C4=CC(NS(=O)(C)=O)=C(Cl)N=C4)=CC=C3N=C1

• Molecular Formula:

  C22H14Cl2FN5O2S

• Molecular Weight:

  502.35

• References & Citations:

  [1]Cara Abecunas, et al. Loss of NF1 in Melanoma Confers Sensitivity to SYK Kinase Inhibition. Cancer Res. 2023 Jan 18;83 (2) :316-331.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1952236-19-9]