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SB-216

CAT: 0804-HY-144898-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-144898-01Size:5 mg
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Description
SB-216 is an BBB-penetrable tubulin polymerization inhibitor. SB-216 can inhibit the proliferation and migration, and induce apoptosis and cell cycle arrest of tumor cells. SB-216 has good in vivo metabolic stability and low toxicity, but its oral bioavailability is limited. SB-216 has antitumor activity and can be used in the research of tumors such as melanoma[1][2].
CAS Number
[2756818-39-8]
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sb-216.html
Concentration
10mM
Purity
99.93
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=CC(OC)=C2)N(C3=C(CCC4)C4=NC(C)=N3)C1
Molecular Formula
C17H18N4O2
Molecular Weight
310.35
References & Citations
[1]Souvik Banerjee, et al. X-ray Crystallography-Guided Design, Antitumor Efficacy, and QSAR Analysis of Metabolically Stable Cyclopenta-Pyrimidinyl Dihydroquinoxalinone as a Potent Tubulin Polymerization Inhibitor. J Med Chem. 2021 Sep 9;64 (17) :13072-13095.|[2]Adeleye K L, et al. Abstract A019: Discovery of a potent and brain-penetrable tubulin inhibitor SB-216 that shows efficacy in primary tumor growth and brain metastasis. Molecular Cancer Therapeutics, 2024, 23 (12_Supplement) : A019-A019.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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