NB-216

• Description :

  NB-216 is an orally active and brain-penetrant BACE-1 inhibitor (IC50 = 17 nM) . NB-216 has a strong inhibitory effect on cathepsin D (IC50 = 1 nM) and cathepsin E (IC50 = 0.4 nM) . NB-216 can be used for the study of Alzheimer's disease[1].

• UNSPSC :

  12352005

• Target :

  Beta-secretase; Cathepsin

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(N[C@H]([C@H](O)CNC1(C2=CC=CC(C(C)C)=C2)CC1)CC3=CC=CC(OCCCCN4)=C3)C5=CC4=CC(COC)=C5

• Molecular Formula :

  C35H45N3O4

• Molecular Weight :

  571.75

• References & Citations :

  [1]Lerchner A, et al. Macrocyclic BACE-1 inhibitors acutely reduce Abeta in brain after po application. Bioorg Med Chem Lett. 2010 Jan 15;20 (2) :603-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  BACE1; Cathepsin D; Cathepsin E

• CAS Number :

  [943924-04-7]