Products for Research Use Only
RegisterLogin

MTX-531

CAT: 0804-HY-162713-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-162713-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. MTX-531 also acts as a weak agonist of PPARγ, with an IC50 of 2.5 µM, helping to alleviate hyperglycemia induced by PI3K inhibitors[1].
CAS Number
2791417-66-6
UNSPSC
12352211
Target
EGFR; PI3K; PPAR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtx-531.html
Purity
99.87
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
ClC1=C(NS(=O)(C)=O)C=C(C2=CC3=C(N=CN=C3N[C@@H](C4=CC=CC=C4)C)C=C2)C=N1
Molecular Formula
C22H20ClN5O2S
Molecular Weight
453.94
References & Citations
[1]Christopher E Whitehead, et al. A first-in-class selective inhibitor of EGFR and PI3K offers a single-molecule approach to targeting adaptive resistance. Nat Cancer. 2024 Jul 11.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ; PPARγ

Related Products

CatalogName
HY-128436KT-531
HY-135447BM-531
HY-107364-01MTX-211
HY-148771-01MTX-23
HY-156872MTX-216
HY-P0231-01AZP-531
HY-149556MTX-241F
HY-D2435MTX-PEG-Cy3
HY-W1008600CRBN ligand-531
HY-180121TBu-MTX-CO-NH-C2-O-C2-N3

Alternative Products

CatalogName
C03278-01MTX-531
A24175-100MTX-531 100mg
A24175-5MTX-531 5mg
A24175-50MTX-531 50mg
A24175-10MTX-531 10mg
BA6343-5.1MTX-211
T78877-01MTX-241F
T88712-01MTX-3937
GTR19220969-01MTX-23

Popular Products