MTX-216

CAT: 0931-MF-0114315-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0114315-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1952236-19-9
Target
Syk|||Apoptosis|||PI3K|||EGFR
Related Pathways
JAK/STAT signaling|||Angiogenesis|||PI3K/Akt/mTOR signaling|||Apoptosis|||Tyrosine Kinase/Adaptors
Bioactivity
MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.
Smiles
N#CC=1C=NC2=CC=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)C=4C=NC(Cl)=C(C4)NS(=O)(=O)C
Molecular Formula
C22H14Cl2FN5O2S
Molecular Weight
502.348
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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