MTX-216

• Target :

  Syk|||Apoptosis|||PI3K|||EGFR

• Related Pathways :

  JAK/STAT signaling|||Angiogenesis|||PI3K/Akt/mTOR signaling|||Apoptosis|||Tyrosine Kinase/Adaptors

• Bioactivity :

  MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.

• Smiles :

  N#CC=1C=NC2=CC=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)C=4C=NC(Cl)=C(C4)NS(=O)(=O)C

• Molecular Formula :

  C22H14Cl2FN5O2S

• Molecular Weight :

  502.348

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1952236-19-9