Products for Research Use Only
RegisterLogin

MTX-216

CAT: 0931-T206251-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T206251-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
CAS Number
1952236-19-9
Target
Syk, Apoptosis, PI3K, EGFR
Related Pathways
JAK/STAT signaling, Angiogenesis, PI3K/Akt/mTOR signaling, Apoptosis, Tyrosine Kinase/Adaptors
Bioactivity
MTX-216 is an ATP-competitive inhibitor targeting both PI3K and EGFR. It simultaneously inhibits Ki-67 and ribosomal S6 phosphorylation, inducing apoptosis in NF1LOF cells. Additionally, MTX-216 suppresses SYK kinase activity with an IC50 of 281 nM. This compound is applicable for melanoma research.
Smiles
N#CC=1C=NC2=CC=C(C=C2C1NC3=CC=C(F)C(Cl)=C3)C=4C=NC(Cl)=C(C4)NS(=O)(=O)C
Molecular Formula
C22H14Cl2FN5O2S
Molecular Weight
502.348
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T88712-01MTX-3937
T88436-01MTX-531
T78877-01MTX-241F
T4296-01MTX-211
T74744-01MTX-23
T203560-01MTX-PEG-Cy3
T28788-01SK-216
T60757-01SB-216
T88635-01LW-216
T68278-01NB-216

Alternative Products

CatalogName
HY-156872MTX-216
BA6343-5.1MTX-211
C03278-100mgMTX-531
GTR19230852-01MTX-241F
HY-148771-01MTX-23
GTR19236325-01MTX-3937

Popular Products