LW-216

• Description:

  LW-216 is a TrxR1 inhibitor that induces Apoptosis. LW-216 has anti-tumor activity[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; TrxR

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Metabolic Enzyme/Protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lw-216.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C(C2=CC=CC=C2)OC3=C(C(OCC4=CC=CC=C4)=CC(O)=C13)OCCCCN5CCCC5

• Molecular Formula:

  C30H31NO5

• Molecular Weight:

  485.57

• References & Citations:

  [1]Wang R, et al. Inducing ubiquitination and degradation of TrxR1 protein by LW-216 promotes apoptosis in non-small cell lung cancer via triggering ROS production. Neoplasia. 2024 Jul;53:101004

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2146090-18-6]