MTX-23

• Description:

  MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1].

• Product Name Alternative:

  PROTAC AR-V7 degrader-2

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H320

• Target:

  Androgen Receptor; Apoptosis; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/mtx-23.html

• Purity:

  99.79

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C (N1[C@@H] (C[C@H] (C1) O) C (N[C@H] (C2=CC=C (C3=C (N=CS3) C) C=C2) C) =O) [C@H] (C (C) (C) C) NC (CCCCNC (COC4=C (C5=CSC (N6CCOCC6) =N5) C=CC (F) =C4F) =O) =O

• Molecular Formula:

  C43H53F2N7O7S2

• Molecular Weight:

  882.05

• Precautions:

  H315, H319, H320

• References & Citations:

  [1]Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2488296-74-6