MTX-23

CAT: 0804-HY-148771-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-148771-01Size:1 mg
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Description
MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1].
CAS Number
[2488296-74-6]
Product Name Alternative
PROTAC AR-V7 degrader-2
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Androgen Receptor; Apoptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtx-23.html
Purity
99.79
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O
Molecular Formula
C43H53F2N7O7S2
Molecular Weight
882.05
Precautions
H315, H319, H320
References & Citations
[1]Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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