MTX-23

• Description :

  MTX-23 is an AR-based PROTAC. MTX-23 inhibits CaP cellular proliferation by degrading AR-V7 and AR-FL. MTX-23 induces apoptosis[1].

• Product Name Alternative :

  PROTAC AR-V7 degrader-2

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H320

• Target :

  Androgen Receptor; Apoptosis; PROTACs

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mtx-23.html

• Purity :

  99.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1[C@@H](C[C@H](C1)O)C(N[C@H](C2=CC=C(C3=C(N=CS3)C)C=C2)C)=O)[C@H](C(C)(C)C)NC(CCCCNC(COC4=C(C5=CSC(N6CCOCC6)=N5)C=CC(F)=C4F)=O)=O

• Molecular Formula :

  C43H53F2N7O7S2

• Molecular Weight :

  882.05

• Precautions :

  H315, H319, H320

• References & Citations :

  [1]Jenny D, et, al. Bi-functional compounds and methods for targeted ubiquitination of androgen receptor. WO2021236695.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2488296-74-6]