MTX-211

• Description:

  MTX-211 (Mol 211) is a dual inhibitor of EGFR and PI3K with IC50 values of [1].

• Product Name Alternative:

  Mol 211

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319

• Target:

  EGFR; PI3K

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/MTX-211.html

• Concentration:

  10mM

• Purity:

  99.81

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  CS(NC1=CC(C2=CC(C(NC3=CC(Cl)=C(F)C=C3)=NC=N4)=C4C=C2)=CN=C1Cl)(=O)=O

• Molecular Formula:

  C20H14Cl2FN5O2S

• Molecular Weight:

  478.33

• Precautions:

  H315, H319

• References & Citations:

  [1]Small molecule inhibitors of egfr and pi3k. WO 2016100347 A2

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  EGFR/ErbB1/HER1; PI3K

• CAS Number:

  [1952236-05-3]