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MTX-241F

CAT: 0804-HY-149556Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-149556Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MTX-241F is a selective small molecule inhibitor targeting EGFR and PI3 kinase family members. MTX-241F is able to penetrate the blood-brain barrier and control tumor growth over the long term. MTX-241F exhibits radiosensitizing activity in patient-derived DIPG neurospheres and may be used in the study of diffuse intrinsic pontine glioma (DIPG) [1].
UNSPSC
12352005
Target
EGFR; PI3K
Type
Reference compound
Related Pathways
JAK/STAT Signaling; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mtx-241f.html
Solubility
10 mM in DMSO
Smiles
NC1=NC=C(C2=CC=C(N=CN=C3N4C5=CC(Cl)=C(F)C=C5CC4)C3=C2)C=N1
Molecular Formula
C20H14ClFN6
Molecular Weight
392.82
References & Citations
[1]Sharma M, et al. Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence. Mol Cancer Ther. 2023 Sep 19..
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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