MTX-241F

• UNSPSC Description:

  MTX-241F is a selective small molecule inhibitor targeting EGFR and PI3 kinase family members. MTX-241F is able to penetrate the blood-brain barrier and control tumor growth over the long term. MTX-241F exhibits radiosensitizing activity in patient-derived DIPG neurospheres and may be used in the study of diffuse intrinsic pontine glioma (DIPG)[1].

• Target Antigen:

  EGFR; PI3K

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/mtx-241f.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=NC=C(C2=CC=C(N=CN=C3N4C5=CC(Cl)=C(F)C=C5CC4)C3=C2)C=N1

• Molecular Weight:

  392.82

• References & Citations:

  [1]Sharma M, et al. Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence. Mol Cancer Ther. 2023 Sep 19..

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported