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JP-153

CAT: 0804-HY-120417-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-120417-02Size:10 mg
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Description
JP-153 is the Src-FAK-Paxillin signaling inhibitor. JP-153 inhibits Src-dependent phosphorylation of paxillin (Y118) and downstream activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation in retinal endothelial cells. JP-153 can be uesd for the study of neovascular eye disease[1].
CAS Number
1802937-26-3
UNSPSC
12352005
Target
FAK; Src
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.45
Solubility
DMSO : 200 mg/mL
Smiles
O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C3=CC=C4C=CC=CC4=C3N1
Molecular Formula
C21H19NO5
Molecular Weight
365.38
References & Citations
[1]Toutounchian JJ, et al. Novel Small Molecule JP-153 Targets the Src-FAK-Paxillin Signaling Complex to Inhibit VEGF-Induced Retinal Angiogenesis. Mol Pharmacol. 2017 Jan;91 (1) :1-13. doi: 10.1124/mol.116.105031. Epub 2016 Nov 9. Erratum in: Mol Pharmacol. 2017 Dec;92 (6) :627.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS Number1802937-26-3
PubChem CID91827392
IUPAC Name4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
Molecular FormulaC21H19NO5
Molecular Weight365.4
XLogP3.9
Topological Polar Surface Area66
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity515
SMILES
COC1=CC(=CC(=C1OC)OC)C2C3=C(C4=CC=CC=C4C=C3)NC(=O)O2
InChI
InChI=1S/C21H19NO5/c1-24-16-10-13(11-17(25-2)20(16)26-3)19-15-9-8-12-6-4-5-7-14(12)18(15)22-21(23)27-19/h4-11,19H,1-3H3,(H,22,23)
InChIKey
NIDMIFDHMDRHLS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS: 1802937-26-3
CID: 91827392
Formula: C21H19NO5
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass365.12632271
Monoisotopic Mass365.12632271
Topological Polar Surface Area66 Ų
Heavy Atom Count27
Formal Charge0
Complexity515
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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