TMP-153

• UNSPSC Description:

  TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis[1].

• Target Antigen:

  Acyltransferase

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/tmp-153.html

• Smiles:

  O=C(NC1=CC=C(F)C=C1F)NC2=C(C3=CC=CC=C3Cl)C4=CC(C)=C(C)C=C4N=C2

• Molecular Weight:

  437.87

• References & Citations:

  [1]Sugiyama Y, et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis. 1995;113(1):71-78.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  128831-46-9