TMP-153

• Description :

  TMP-153 is an orally active inhibitor of ACAT with an IC50 value of approximately 5-10 nM against hepatic and intestinal ACAT in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis[1].

• UNSPSC :

  12352005

• Target :

  Acyltransferase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/tmp-153.html

• Purity :

  99.34

• Smiles :

  O=C(NC1=CC=C(F)C=C1F)NC2=C(C3=CC=CC=C3Cl)C4=CC(C)=C(C)C=C4N=C2

• Molecular Formula :

  C24H18ClF2N3O

• Molecular Weight :

  437.87

• References & Citations :

  [1]Sugiyama Y, et al. TMP-153, a novel ACAT inhibitor, inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters. Atherosclerosis. 1995;113 (1) :71-78.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [128831-46-9]