BS-153

• Description:

  BS-153 is a novel synthetic oxazolidinone agent with anti-inflammatory activities by blocking the activation of the NF-κB/PKCθ pathway. BS-153 inhibits the expression levels of iNOS and COX-2 and pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) on LPS-stimulated RAW264.7 cells[1].

• UNSPSC:

  12352005

• Target:

  NF-κB

• Related Pathways:

  NF-κB

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC(F)(F)C1=C(NC(C2=CC=C(N3CCC(N4CCOCC4)CC3)C(C#N)=C2)=O)C=NN1C5=CC=C(Cl)C=C5

• Molecular Formula:

  C27H26ClF3N6O2

• Molecular Weight:

  558.98

• References & Citations:

  [1]Liyan Xu, et al. A novel synthetic oxazolidinone derivative BS-153 attenuated LPS-induced inflammation via inhibiting NF-κB/pkcθ signaling pathway. Fish Shellfish Immunol. 2025 Jun:161:110292.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1935692-54-8]