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JP-2-196 (hydrochloride)

CAT: 0804-HY-W854844BSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-W854844BSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JP-2-196 hydrochloride is a covalent molecular glue degrader targeting RNF126. JP-2-196 hydrochloride induces the formation of a ternary complex between RNF126 and target proteins (e.g., BRD4, AR-V7), promoting their ubiquitination and proteasomal degradation. JP-2-196 hydrochloride is promising for research of cancers (e.g., prostate cancer, leukemia) [1].
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; Molecular Glues
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
O=C(C1=CC=C(OC)C=C1)/C=C/C(N2CCNCC2)=O.Cl
Molecular Formula
C15H19ClN2O3
Molecular Weight
310.78
References & Citations
[1]Toriki ES, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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