Products for Research Use Only
RegisterLogin

JP-163-16

CAT: 0804-HY-174864-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-174864-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
JP-163-16 is a RelA/p65 PROTAC degrader. JP-163-16 selectively reduces the expression of RelA/p65 in a proteasome-dependent manner in cells. JP-163-16 can induce cell apoptosis by inhibiting the NF-κB signaling pathway. JP-163-16 can be used for research on RelA/p65-dependent tumours, such as chronic lymphocytic leukaemia (CLL). (Pink: RelA/p65 Ligand ; Blue: CRBN Ligand (HY-A0003) ; Black: Linker; CRBN Ligand+Linker (HY-160241) ).
UNSPSC
12352005
Target
Apoptosis; NF-κB; PROTACs
Related Pathways
Apoptosis; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(NC(CCCOC2=C(OC)C=C3C(N=C[C@@](CCC4)([H])N4C3=O)=C2)=O)C=C1)CCCCCNC5=CC=CC6=C5CN(C(CC7)C(NC7=O)=O)C6=O
Molecular Formula
C42H47N7O8
Molecular Weight
777.86
References & Citations
[1]Jin P, et al. Design, synthesis and evaluation of pyrrolobenzodiazepine (PBD) -based PROTAC conjugates for the selective degradation of the NF-κB RelA/p65 subunit. RSC Med Chem. 2025 May 8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon; RelA/p65

Related Products

CatalogName
HY-120417-01JP-153
HY-115590JP-11646
HY-163035-01EM-163
HY-115826AB-163
HY-178163Zharp1-163
HY-174231EGFR-IN-163
HY-120429-01SKLB-163
HY-161883JP-2-249
HY-163691Antitumor agent-163
HY-U00038ENS-163 phosphate

Alternative Products

CatalogName
T211198-01JP-163-16
MBS5775284-01JP-8g
TN4015JP-2
GTR19231834JP-11646
MBS5781891-01JP-8
T206442-01JP-153
T211095-01EGFR-IN-163
466240EM 163
406539ATN-163
MBS5778942163-BP3

Popular Products