JP-2-249

• Description:

  JP-2-249 is a molecular glue that acts as a potent degrader of SMARCA2. JP-2-249 shows decreasing protein level of SMARCA2 in MV-4-11 cells at 1-10 μM[1].

• UNSPSC:

  12352005

• Target:

  Epigenetic Reader Domain; Molecular Glues

• Type:

  Reference compound

• Related Pathways:

  Epigenetics; PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/jp-2-249.html

• Smiles:

  COC1=CC=C(C(/C=C/C(N2CCN(C3=C(N)N=NC(C4=CC=CC=C4O)=C3)CC2)=O)=O)C=C1

• Molecular Formula:

  C25H25N5O4

• Molecular Weight:

  459.50

• References & Citations:

  [1]Ethan S Toriki, et al. Rational Chemical Design of Molecular Glue Degraders. ACS Cent Sci. 2023 Apr 11;9 (5) :915-926.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3036530-41-0]