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JP-153

CAT: 0931-T206442-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206442-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1802937-26-3
Target
FAK, Src
Related Pathways
Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis
Bioactivity
JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
Smiles
O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1
Molecular Formula
C21H19NO5
Molecular Weight
365.379
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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