JP-153

• Target :

  FAK|||Src

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Cytoskeletal Signaling|||Angiogenesis

• Bioactivity :

  JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.

• Smiles :

  O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1

• Molecular Formula :

  C21H19NO5

• Molecular Weight :

  365.379

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1802937-26-3