AV-153

CAT: 0804-HY-135218Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-135218Size:1 Each
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Description
AV-153, a 1,4-dihydropyridine (1,4-DHP) derivative, is an antimutagenic. AV-153 intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro. AV-153 interacts with thymine and cytosine and has an influence on poly (ADP) ribosylation. AV-153 has anti-cancer activity[1][2][3].
CAS Number
[27296-05-5]
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/av-153.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)NC(C)=C(C(OCC)=O)C1C(O[Na])=O)OCC
Molecular Formula
C14H18NNaO6
Molecular Weight
319.29
References & Citations
[1]Nadezhda I Ryabokon, et al. A 1,4-dihydropyridine Derivative Reduces DNA Damage and Stimulates DNA Repair in Human Cells in Vitro. Mutat Res. 2005 Nov 10;587 (1-2) :52-8.|[2]E Buraka, et al. DNA-binding Studies of AV-153, an Antimutagenic and DNA Repair-Stimulating Derivative of 1,4-dihydropiridine. Chem Biol Interact. 2014 Sep 5;220:200-7.|[3]Lidija Milkovic, et al. Antioxidative 1,4-Dihydropyridine Derivatives Modulate Oxidative Stress and Growth of Human Osteoblast-Like Cells In Vitro. Antioxidants (Basel) . 2018 Sep 19;7 (9) :123.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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