ALK5-IN-83

• Target:

  TGF-beta/Smad

• Related Pathways:

  Stem Cells

• Bioactivity:

  ALK5-IN-83 (compound 13b) is an ALK5 inhibitor with an IC50 of 0.13 ?M. It suppresses TGF-?1-induced Smad2 phosphorylation and cell motility in A549 cells.

• Smiles:

  O=C(NC1=C(Br)C=C(C=C1C(F)(F)F)C(F)(C(F)(F)F)C(F)(F)F)C2=CC=CC(=C2F)N(C(=O)C3=CC=C(F)C=C3)CC4CC4

• Molecular Formula:

  C20H23N7O2S

• Molecular Weight:

  425.51

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C