STAT3-IN-27

STAT3-IN-27

• UNSPSC Description: STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 μM) and STAT3 transcription (IC50 is 22.57 nM). STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model[1].
• Target Antigen: Apoptosis; STAT
• Type: Reference compound
• Related Pathways: Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-in-27.html
• Smiles: O=C(C1C2ON=C1C)C3=C(C=C(C(NCCCN4CCCC4)=O)S3)C2=O
• Molecular Weight: 375.44
• References & Citations: [1]Zhang L, et al., Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level. Eur J Med Chem. 2024 Jun 5;272:116448.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported