STAT3-IN-27

• UNSPSC Description:

  STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 μM) and STAT3 transcription (IC50 is 22.57 nM). STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model[1].

• Target Antigen:

  Apoptosis; STAT

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stat3-in-27.html

• Smiles:

  O=C(C1C2ON=C1C)C3=C(C=C(C(NCCCN4CCCC4)=O)S3)C2=O

• Molecular Weight:

  375.44

• References & Citations:

  [1]Zhang L, et al., Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level. Eur J Med Chem. 2024 Jun 5;272:116448.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported