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STAT3-IN-27

CAT: 0804-HY-161644Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161644Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-27 (Compound 41) is an orally active inhibitor for phosphorylation of STAT3 (KD is 4.4 μM) and STAT3 transcription (IC50 is 22.57 nM) . STAT3-IN-27 inhibits proliferation of various cancer cells with IC50 of 10-500 nM. STAT3-IN-27 arrests the cell cycle at G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116, inhibits cell migration of HCT116. STAT3-IN-27 exhibits antitumor efficacy in mouse model[1].
UNSPSC
12352005
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-27.html
Smiles
O=C(C1C2ON=C1C)C3=C(C=C(C(NCCCN4CCCC4)=O)S3)C2=O
Molecular Formula
C18H21N3O4S
Molecular Weight
375.44
References & Citations
[1]Zhang L, et al., Exploration of novel isoxazole-fused quinone derivatives as anti-colorectal cancer agents through inhibiting STAT3 and elevating ROS level. Eur J Med Chem. 2024 Jun 5;272:116448.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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