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STAT3-IN-1

CAT: 0804-HY-100753-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100753-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-1 (compound 7d) is an excellent, selective and orally active STAT3 inhibitor, with IC50 values of 1.82 μM and 2.14 μM in HT29 and MDA-MB 231 cells, respectively. STAT3-IN-1 (compound 7d) induces tumor cells apoptosis[1].
CAS Number
2059952-75-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-1.html
Purity
96.28
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
COC1=CC(OC)=CC(/C=C/C2=CC=C(NC(/C=C/C3=CC(OC)=C(OC)C(OC)=C3)=O)C=C2)=C1
Molecular Formula
C28H29NO6
Molecular Weight
475.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Li S, et al. Discovery of oral-available resveratrol-caffeic acid based hybrids inhibiting acetylated and phosphorylated STAT3 protein. Eur J Med Chem. 2016 Nov 29;124:1006-1018.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

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