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STAT3-IN-27

CAT: 0013-GTR19262508-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19262508-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-27 (Compound 41) is an orally active STAT3 inhibitor that impedes STAT3 phosphorylation with a KD of 4.4 μM and suppresses STAT3 transcriptional activity with an IC50 of 22.57 nM. It inhibits the proliferation of various cancer cells with an IC50 ranging from 10 to 500 nM. STAT3-IN-27 causes cell cycle arrest at the G2/M phase, induces mitochondrial dysfunction and apoptosis in HCT116 cells, and inhibits HCT116 cell migration. It exhibits antitumor effects in mouse models.
Field of Research
Cancer Biology, Cell Biology, Signal Transduction, Stem Cell & Developmental Biology
Molecular Formula
C18H21N3O4S
Storage Conditions
-20°C
Notes
For research use only.

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