STAT3-IN-20

• Description:

  STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM) . STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively) . STAT3-IN-20 induces cell cycle arrest and apoptosis[1].

• UNSPSC:

  12352005

• Target:

  STAT

• Type:

  Reference compound

• Related Pathways:

  JAK/STAT Signaling; Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/stat3-in-20.html

• Purity:

  99.83

• Solubility:

  DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)

• Smiles:

  FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1

• Molecular Formula:

  C30H27F4N7S

• Molecular Weight:

  593.64

• References & Citations:

  [1]Wang R, et al. Discovery, Optimization, and Evaluation of Novel N- (Benzimidazol-5-yl) -1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2768427-54-7]