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STAT3-IN-20

CAT: 0804-HY-155982-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-155982-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
STAT3-IN-20 (Compound 40) is a selective STAT3 inhibitor (IC50: 0.65 μM) . STAT3-IN-20 binds the SH2 domain to inhibit STAT3 phosphorylation, translocation, and downstream gene transcription. STAT3-IN-20 exhibits antiproliferative activities against STAT3-overactivated DU145 and MDA-MB-231 cancer cells (IC50: 2.97 μM and 3.26 μM respectively) . STAT3-IN-20 induces cell cycle arrest and apoptosis[1].
CAS Number
[2768427-54-7]
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-20.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
FC1=CC=C(C2=NC3=CC(NC4=NN=C(S4)C5=CC=C(C=C5)C(F)(F)F)=C(C=C3N2C6CC6)N7CCN(CC7)C)C=C1
Molecular Formula
C30H27F4N7S
Molecular Weight
593.64
References & Citations
[1]Wang R, et al. Discovery, Optimization, and Evaluation of Novel N- (Benzimidazol-5-yl) -1,3,4-thiadiazol-2-amine Analogues as Potent STAT3 Inhibitors for Cancer Treatment. J Med Chem. 2023 Aug 18.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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