STAT3-IN-18

STAT3-IN-18

• CAS Number: 2668267-41-0
• UNSPSC Description: STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
• Target Antigen: Apoptosis; COX; JAK; STAT
• Type: Reference compound
• Related Pathways: Apoptosis;Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/stat3-in-18.html
• Solubility: 10 mM in DMSO
• Smiles: [Cl-][Pt+4]([Cl-])([NH3])([NH3])([OH-])[O-]C(COC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2)=O
• Molecular Weight: 630.38
• References & Citations: [1]Cai L, Wang Y, Chen H, Tan Y, Yang T, Zhang S, Guo Z, Wang X. Platinum(IV) Complexes as Inhibitors of STAT3 and Regulators of the Tumor Microenvironment To Control Breast Cancer. J Med Chem. 2023 Aug 24;66(16):11351-11364.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported