Products for Research Use Only
RegisterLogin

STAT3-IN-25

CAT: 0804-HY-160496-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-160496-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
STAT3-IN-25 (Compound 2p) is a potent STAT3 inhibitor with a p-trifluoroethoxy benzyl substituent. STAT3-IN-25 shows STAT3 luciferase inhibition activity using HEK293T cells with an IC50 of 22.3 nM and ATP production inhibition activity using BxPC-3 cells with an IC50 of 32.5 nM. STAT3-IN-25 has the potential for pancreatic cancer research[1].
CAS Number
2591440-75-2
UNSPSC
12352005
Target
STAT
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-25.html
Purity
99.36
Solubility
DMSO : 5 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C(C(N1C)=CC2=C1C=C(OC3=NC=C(C4=NC(C5=CC=C(C(F)(F)F)C=C5)=NO4)N=C3)C=C2)N6CCN(CC7=CC=C(OCC(F)(F)F)C=C7)CC6
Molecular Formula
C36H29F6N7O4
Molecular Weight
737.65
References & Citations
[1]Peng He, et al. Discovery of a Highly Potent and Orally Bioavailable STAT3 Dual Phosphorylation Inhibitor for Pancreatic Cancer Treatment. J Med Chem. 2022 Nov 24;65 (22) :15487-15511.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

Related Products

CatalogName
HY-163526-01STAT3-IN-26
HY-155982-01STAT3-IN-20
HY-161864STAT3-IN-29
HY-144870STAT3-IN-7
HY-100753-01STAT3-IN-1
HY-179468STAT3-IN-49
HY-177990-01STAT3-IN-52
HY-155808STAT3-IN-18
HY-146666STAT3-IN-9
HY-128588-01STAT3-IN-3

Alternative Products

CatalogName
BA6402-5STAT3-IN-25
sc-293059P-Stat3 (pS727.25)
sc-293059 XP-Stat3 (pS727.25) X
GTR15219365Lentiviral mouse Stat3 shRNA (UAS) - Lentiviral mouse Stat3 shRNA (UAS) (25)
GTR15219371Lentiviral mouse Stat3 shRNA (UAS) - Lentiviral mouse Stat3 shRNA (UAS, RFP) (25)
GTR15219374Lentiviral mouse Stat3 shRNA (UAS) - Lentiviral mouse Stat3 shRNA (UAS, iRFP) (25)
335744-01Stat3

Popular Products