NF-κB-IN-16

• UNSPSC Description:

  NF-κB-IN-16 (compound 9) is a complex (Pt(IV) complex) of NF-κB inhibitor and Cisplatin (HY-17394), which has high efficacy and low toxicity in anti-tumor activity. active. NF-κB-IN-16 can cause DNA damage, induce mitochondrial dysfunction, produce reactive oxygen species, and induce apoptosis through the mitochondrial pathway and endoplasmic reticulum stress. NF-κB-IN-16 potently inhibits the NF-κB/MAPK signaling pathway and disrupts PI3K/AKT signaling. NF-κB-IN-16 also exhibits excellent in vivo antitumor efficiency and low toxicity in A549 or A549/CDDP xenograft models[1].

• Target Antigen:

  Apoptosis; NF-κB

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;NF-κB

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/nf-κb-in-16.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC1=C(C(OC)=CC(C(/C=C/C2=CC=C(C(OCCOC(CCCC(O[Pt]([NH3])(Cl)(Cl)([NH3])Cl)=O)=O)=C2)OC)=O)=C1)OC

• Molecular Weight:

  837.01

• References & Citations:

  [1]Wang M, et al. Novel NF-κB Inhibitor-Conjugated Pt(IV) Prodrug to Enable Cancer Therapy through ROS/ER Stress and Mitochondrial Dysfunction and Overcome Multidrug Resistance. J Med Chem. 2024 Apr 25;67(8):6218-6237.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported